Reconstitution and Storage | ABRYSVO Website for HCPs

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Reconstitution and storage¹

Vaccine reconstitution with Pfizer's reconstitution kit

Designed for convenience

The reconstitution process does not require a needle.

Supplied: Syringe containing diluent, vial containing lyophilized RSVpreF vaccine, and vial adapter.
Not included in kit: An alcohol swab and a needle for intramuscular administration.

ABRYSVO can be reconstituted in 3 steps

STEP 1: ATTACH vial adapter

Peel off the top cover from the vial adapter packaging and remove the flip-off cap from the vial.
While keeping the vial adapter in its packaging, centre it over the vial’s stopper and connect with a straight downward push. Do not push the vial adapter in at an angle as it may result in leaking. Remove the packaging.

STEP 2: RECONSTITUTE lyophilized vaccine component to form ABRYSVO

For all syringe assembly steps, hold the syringe only by the Luer lock adapter. This will prevent the Luer lock adapter from detaching during use.
Twist to remove the syringe cap, then twist to connect the syringe to the vial adapter. Stop turning when you feel resistance.
Inject the entire contents of the syringe into the vial. Hold the plunger rod down and gently swirl the vial until the powder is completely dissolved (less than 1 minute). Do not shake.

STEP 3: WITHDRAW reconstituted vaccine

Invert the vial completely, and slowly withdraw the entire contents into the syringe to ensure a 0.5 mL dose of ABRYSVO.
Twist to disconnect the syringe from the vial adapter.
Attach a sterile needle suitable for IM injection.

Storage information

Before reconstitution: Store in a refrigerator (2 °C–8 °C). Do not freeze.
After reconstitution: ABRYSVO should be administered immediately (within 4 hours). Reconstituted ABRYSVO can be stored between 15 °C and 30 °C. Do not freeze.

For complete dosing and administration information, please consult the Product Monograph.

RSVpreF: respiratory syncytial virus prefusion F; IM: intramuscular

About ABRYSVO

About RSV

Learn more about respiratory syncytial virus and its impact on high-risk populations.

Efficacy and Safety Profiles

Investigate ABRYSVO’s efficacy and safety profiles in infants and individuals ≥ 60 years of age.

Reference:

ABRYSVO Product Monograph. Pfizer Canada ULC. May 29, 2024.

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